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Severe Eosinophilia in an Infant With Congenital Acute Myeloid Leukemia With t(3;4;6)(q26;q25;q21): A Case Report

Harisi, Marieta MD*; Douna, Varvara MD*; Baka, Margarita MD; Servitzoglou, Marina MD; Kosmidi, Helen MD; Anastasiou, Theodora MD*

Journal of Pediatric Hematology/Oncology: August 2010 - Volume 32 - Issue 6 - p 497-500
doi: 10.1097/MPH.0b013e3181e40e1b
Clinical and Laboratory Observations

We report a case of acute myeloid leukemia with morphologic features of M7 according to the FAB (French-American-British) classification and severe eosinophilia in the peripheral blood and bone marrow at diagnosis. We consider it as congenital leukemia, as the symptoms started in the first month of life of the affected child. This case of leukemia is characterized by t(3;4;6)(q26;q25;q21) cytogenetic abnormality. The blasts in flow cytometry analysis expressed markers of megakaryocytic lineage along with expression of myeloperoxidase in 30% of them. This type of acute myelogenous leukemia with severe eosinophilia can be considered as a distinct clinicopatologic entity.

*Hematology Laboratory

Pediatric Hematology Oncology Department “P.&A. Kyriakou” Children's Hospital, Thivon and Levadias, Athens, Greece

Reprints: Marina Servitzoglou, MD, Pediatric Hematology Oncology Department “P.&A. Kyriakou” Children's Hospital, Thivon and Levadias, Athens 11527, Greece (e-mail: marinaser@live.com).

Received for publication November 17, 2009; accepted March 31, 2010

© 2010 Lippincott Williams & Wilkins, Inc.