Moyamoya is a cerebral vasculopathy of unknown etiology rarely described as a late effect after the treatment of childhood cancer. We describe a 12-year-old female who developed moyamoya after the completion of systemic chemotherapy, surgery, and adjuvant interferon α for osteosarcoma with pulmonary metastases. Given the importance of characterizing late effects after the treatment of childhood cancer, the potential role of interferon α in the development of moyamoya is discussed.
*Division of Hematology, Department of Pediatrics, Children's Hospital of Orange County, Main Street, Orange
†Department of Neurosurgery, Stanford University School of Medicine, Pasteur Drive, Stanford
‡Department of Radiology
§Division of Hematology/Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Le Conte Avenue, Los Angeles, CA
Reprints: David Buchbinder, MD, MSHS, Division of Hematology, Department of Pediatrics, Children's Hospital of Orange County, Main Street, 455 S. Main Street, Orange (e-mail: firstname.lastname@example.org).
Received for publication August 18, 2009; accepted April 21, 2010