Skip Navigation LinksHome > August 2010 - Volume 32 - Issue 6 > Metanephric Adenoma in a 2-year-old Child: Case Report and I...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181e34de1
Clinical and Laboratory Observations

Metanephric Adenoma in a 2-year-old Child: Case Report and Immunohistochemical Observations

Mei, Hong MD*; Zheng, Liduan PhD, MD; Zhou, Chengkai MD; Tong, Qiangsong PhD, MD*

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Abstract

Renal metanephric adenoma (MA) is an extremely rare benign tumor, especially in children under the age of 12 years old. In this article, we report a case of MA that was incidentally discovered in a 2-year-old girl by ultrasound. Magnetic resonance scan revealed a mass of right kidney that was hypointense and hyperintense on T1- and T2-weighted images, respectively. Laparoscopic nephron-sparing surgery was carried out to remove the lesion. Histopathologic examination of the specimen revealed MA with clear surgical margins. Immunohistochemically, the tumor cells showed focal reactivity for CD56, pan-cytokeratin (AE1/AE3), and epithelial membrane antigen, and negative reactivity for Wilms' tumor 1 gene product. Meanwhile, the tumor stroma was diffusely positive for vimentin. We also review the literature regarding the clinical, imaging, and histopathologic features of this lesion in the pediatric population.

© 2010 Lippincott Williams & Wilkins, Inc.

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