Some iron-overloaded patients have problems being treated with iron chelators. We therefore retrospectively studied 7 iron-overloaded thalassemic patients. Within the same week, patients received 20 to 30 mg/kg/d of oral deferasirox for 4 consecutive days, then a subcutaneous infusion of 20 to 40 mg/kg/d of desferrioxamine for 8 to 12 hours on the next 3 consecutive days. The median treatment duration was 25 months (range, 8 to 32). All of the patients showed a decrease in serum ferritin without any side effects. The protocol, combining deferasirox and desferrioxamine in sequence, was effective and safe: more cases should be studied.
Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
This study had no funding support.
Reprints: Arunee Jetsrisuparb, MD, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand (e-mail: firstname.lastname@example.org, email@example.com).
Received for publication December 15, 2009; accepted March 8, 2010