Skip Navigation LinksHome > July 2010 - Volume 32 - Issue 5 > Retrospective Study on the Combination of Desferrioxamine an...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181e015b0
Clinical and Laboratory Observations

Retrospective Study on the Combination of Desferrioxamine and Deferasirox for Treatment of Iron-overloaded Thalassemic Patients: First Evidence of More Than 2 Years

Jetsrisuparb, Arunee MD; Komvilaisak, Patcharee MD; Wiangnon, Surapon MD; Jetsrisuparb, Charoon MD

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Abstract

Some iron-overloaded patients have problems being treated with iron chelators. We therefore retrospectively studied 7 iron-overloaded thalassemic patients. Within the same week, patients received 20 to 30 mg/kg/d of oral deferasirox for 4 consecutive days, then a subcutaneous infusion of 20 to 40 mg/kg/d of desferrioxamine for 8 to 12 hours on the next 3 consecutive days. The median treatment duration was 25 months (range, 8 to 32). All of the patients showed a decrease in serum ferritin without any side effects. The protocol, combining deferasirox and desferrioxamine in sequence, was effective and safe: more cases should be studied.

© 2010 Lippincott Williams & Wilkins, Inc.

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