Skip Navigation LinksHome > July 2010 - Volume 32 - Issue 5 > First Report of Successful Stem Cell Transplantation in a Pa...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181df614b
Clinical and Laboratory Observations

First Report of Successful Stem Cell Transplantation in a Patient With Sickle Cell Hemoglobin D Disease

Hamidieh, Amir Ali MD; Jalili, Mahdi MD; Khojasteh, Omid MD; Ghavamzadeh, Ardeshir MD

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Abstract

Sickle cell hemoglobin D disease is a rare variant of sickle cell disease. Affected patients suffer from episodes of acute exacerbation of clinical course with a wide range of manifestations such as acute chest syndrome, stroke, painful vaso-occlusive crises, acute sequestration crises, joint necrosis, organ failure, infections, and temporary aplastic crises, collectively called sickling crises. Conventional treatments for patients with sickle cell disease include hydroxyurea therapy and prophylactic red blood cell transfusion. However, morbidity and mortality rates remain high with these remedies. In this article, we report hematopoietic stem cell transplantation as an alternative treatment in children with high-risk factors. According to our knowledge and an extensive review of the literature, stem cell transplantation in sickle cell hemoglobin D disease previously has not been reported in any published study and our patient is the first case.

© 2010 Lippincott Williams & Wilkins, Inc.

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