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Dietary Water and Sodium Intake of Children and Adolescents With Sickle Cell Anemia

Fowler, Katherine T. MS, RD*; Williams, Ruth MS, RD, EdD; Mitchell, Carol O. PhD, RD*; Levy, Marian C. DrPH, RD*; Pope, Lucille F. MS, RD; Smeltzer, Matthew P. MS; Wang, Winfred C. MD§

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181df615f
Original Articles

Dietary fluid and sodium intake may influence the risk for vasoocclusive events in persons with sickle cell anemia (SCA). The objective of this study was to examine the dietary intake of water and sodium in children and adolescents with SCA and identify possible factors influencing intake. We compared water (mL) and sodium (mg) intake in 21 patients with SCA, aged 5 to 18 years, to reported adequate intake for water, daily fluid requirement, upper limit for sodium, and National Health and Nutrition Examination Survey 2005 to 2006 data for sodium, and sociodemographic factors. Dietary intake from 3-day food records was evaluated retrospectively. Median water intake was significantly lower than adequate intake, and median sodium intake was significantly higher than sodium upper limit. Sociodemographic factors were not associated with dietary water or sodium intake. Our results suggest that children and adolescents with SCA would benefit from education regarding increasing fluid intake and limiting high sodium foods.

Author Information

*Department of Health and Sport Sciences, University of Memphis

Departments of Clinical Nutrition Services


§Hematology, St Jude Children's Research Hospital, Memphis, TN

Supported by The American Lebanese Syrian Associated Charities (ALSAC), Thrasher Research Fund.

Reprints: Katherine T. Fowler, MS, RD, 600 12th Avenue South Unit 512, Nashville, TN 37203 (e-mail:

Received for publication August 5, 2009; accepted February 21, 2010

© 2010 Lippincott Williams & Wilkins, Inc.