Skip Navigation LinksHome > July 2010 - Volume 32 - Issue 5 > Depression, Anxiety, and Stress Comorbidities in Sickle Cell...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181d869d5
Original Articles

Depression, Anxiety, and Stress Comorbidities in Sickle Cell Anemia Patients With Vaso-occlusive Crisis

Mahdi, Najat MD* †; Al-Ola, Khadija MD*; Khalek, Nahed Abdel MD; Almawi, Wassim Y. PhD

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We investigated the association of sickle cell anemia (SCA) vaso-occlusive crisis (VOC) with depression, anxiety, and stress disorders among Bahraini patients and controls. This was a cross-sectional study that involved administering Depression Anxiety Stress Scales (DASS-21) consisting of structured depression, anxiety, and stress scales to SCA patients with (n=138) and without (n=105) VOC. Multinomial regression and correlation analysis were used in assessing the association of VOC with depression and/or anxiety and/or stress, after adjusting for other covariates. Significantly higher proportion of VOC patients was found among the severe-extremely severe anxiety (P<0.002) and stress (P=0.001) groups; the frequency of depressed patients was comparable between the 2 groups. Adjusting for age, sex, income, number of affected individuals per family, and HbS levels, mild-moderate (P=0.042; odds ratio=2.00; 95% confidence interval=1.03-3.91) and severe-extremely severe (P=0.004; odds ratio=4.43; 95% confidence interval=1.59-12.34) anxiety were independently associated with VOC. Both depression and stress were not associated with VOC after adjusting for these covariates. These results suggest a positive contribution of VOC to the increased rates of anxiety disorders among SCA patients, thereby recommending counseling SCA patients with repeated VOC for these psychologic comorbidities, in particular anxiety.

© 2010 Lippincott Williams & Wilkins, Inc.


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