Splenic Rupture in a Newborn With Severe Hemophilia—Case Report and ReviewTengsupakul, Supatida MD; Sedrak, Aziza MD; Freed, Jennifer MD; Martinez-Carde, Lynda RN; Fireman, Fernando MD, MS; Pierre, Louisdon MD; Sadanandan, Swayam MDJournal of Pediatric Hematology/Oncology: May 2010 - Volume 32 - Issue 4 - pp 323-326 doi: 10.1097/MPH.0b013e3181d640ae Clinical and Laboratory Observations Abstract Author Information Life-threatening splenic rupture is rare in neonates with severe hemophilia. There are only 3 cases of splenic rupture in neonates with hemophilia reported in the literature. We present the case of an infant, born to a hemophilia A carrier mother. The infant was asymptomatic until discharge at 48 hours of age, but presented on the third day of life with shock, abdominal distension, and severe anemia. Computed tomography of the abdomen confirmed the diagnosis of splenic rupture with hemoperitoneum. The infant recovered after extensive supportive care surgery and factor replacement. Pediatric Hematology/Oncology, Department of Pediatrics, The Brooklyn Hospital Center, Brooklyn, NY Reprints: Swayam Sadanandan, MD, Pediatric Hematology/Oncology, Department of Pediatrics, The Brooklyn Hospital Center, 121 DeKalb Ave, Brooklyn, 11201 NY (e-mail: firstname.lastname@example.org). Received for publication August 24, 2009; accepted January 15, 2010 © 2010 Lippincott Williams & Wilkins, Inc.