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Multiple Unrelated Chromosomal Abnormalities in Host Cells After Cord Blood Transplantation

Moon, HeeWon MD*; Cho, JinHee MD*; Hur, Mina MD, PhD*; Yun, Yeo-Min MD*; Han, Sung-Hee MD; Lee, Mark Hong MD

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181d746d2
Clinical and Laboratory Observations
Abstract

We experienced a 16-year-old patient with T-cell acute lymphoblastic leukemia, who had multiple unrelated chromosomal abnormalities in host cells after chemotherapy and cord blood transplantation (CBT). In 7 consecutive cytogenetic studies after CBT, he showed various chromosomal abnormalities including t(1;11)(p32;q23), t(8;21)(q22.2;q22.2), t(6;10)(p21.3;q26), and del(7) (q22q34). His chromosomal abnormalities were unstable and different in each cytogenetic study except del(7)(q22q34). He had neither anemia nor leukopenia, and his thrombocytopenia continuously improved after CBT. He was clinically stable for 2.5 years despite his complex chromosomal abnormalities. The clinical relevance of genetic instabilities in host cells after CBT is unclear, and long-term monitoring with additional cases is needed.

Author Information

*Department of Laboratory Medicine, Konkuk University School of Medicine

Seoul Clinical Laboratories

Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea

Reprints: Mina Hur, MD, PhD, Department of Laboratory Medicine, Konkuk University School of Medicine, Konkuk University Hospital, 4-12, Hwayang-dong, Gwangjin-gu, Seoul 143-729, Korea (e-mail: dearmina@hanmail.net).

Received for publication June 3, 2009; accepted January 29, 2010

© 2010 Lippincott Williams & Wilkins, Inc.