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Langerhans Cell Histiocytosis With Thyroid and Lung Involvement in a Child: A Case Report

Lin, Chien-Heng MD*; Lin, Wei-Ching MD; Chiang, I-Ping MD; Ho, Yung-Jen MD; Peng, Ching-Tien MD§ ∥; Wu, Kang-Hsi MD§

Journal of Pediatric Hematology/Oncology: May 2010 - Volume 32 - Issue 4 - pp 309-311
doi: 10.1097/MPH.0b013e3181c4de1a
Clinical and Laboratory Observations

Langerhans cell histiocytosis (LCH), a monoclonal disease of histiocytes, may involve several organ systems but rarely primarily involves the thyroid gland. This report presents an extremely rare case of LCH of the thyroid and lungs in a 3-year-old boy who presented with a neck mass for several weeks. The patient subsequently underwent chemotherapy with resolution of the goiter and lung findings, and the patient remained in complete remission 1 year after chemotherapy. LCH of the thyroid should be considered in the differential diagnosis of a child with a thyroid mass. Pulmonary examination should be done in these patients.

*Department of Pediatrics, Jen-Ai Hospital

Departments of Radiology


§Pediatrics, China Medical University Hospital

Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan

This study was supported by Grant DMR-95-012 from China Medical University Hospital, Taiwan. Reprints: Kang-Hsi Wu, MD, No 2, Yuh-Der Road, Department of Pediatrics, China Medical University Hospital, Taichung 404, Taiwan (e-mail:

Received for publication August 3, 2009; accepted October 6, 2009

© 2010 Lippincott Williams & Wilkins, Inc.