Skip Navigation LinksHome > April 2010 - Volume 32 - Issue 3 > Vincristine-induced Peripheral Neuropathy in a Neonate With...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181d419ad
Online Articles: Clinical and Laboratory Observations

Vincristine-induced Peripheral Neuropathy in a Neonate With Congenital Acute Lymphoblastic Leukemia

Baker, Steven K. MSc, MD, FRCP(C), CSCN; Lipson, David M. MD

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Abstract

We report the case of a 46-day-old boy with a fulminant vincristine-induced peripheral neuropathy after treatment for congenital acute lymphoblastic leukemia. Flaccid paralysis developed at the end of the first phase of induction, requiring intubation and ventilation for 51 days. Treatment was initiated with levocarnitine, N-acetylcysteine, and pyridoxine and progressive reversal of the neuropathy occurred over the next 4 months. Potential differences in pathogenesis and presentation of vincristine neurotoxicity and Guillian-Barre syndrome in the neonate are discussed.

© 2010 Lippincott Williams & Wilkins, Inc.

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