Skip Navigation LinksHome > November 2009 - Volume 31 - Issue 11 > Severe Ceftriaxone-induced Hemolysis Complicated by Diffuse...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181b7eda2
Clinical and Laboratory Observations

Severe Ceftriaxone-induced Hemolysis Complicated by Diffuse Cerebral Ischemia in a Child With Sickle Cell Disease

Schuettpelz, Laura G. MD, PhD*; Behrens, Deanna MD; Goldsmith, Matthew I. MD; Druley, Todd E. MD, PhD*

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Abstract

Ceftriaxone-induced hemolytic anemia is a rare and often fatal phenomenon. We report here the case of a 6-year-old female with sickle cell disease who survived a brisk and profound hemolytic reaction, resulting in hemoglobin of 0.4 g/dL, after ceftriaxone infusion. Ongoing hemolysis was abrogated with aggressive supportive care, but the patient suffered extensive neurologic sequelae as a result of the event. Serologic testing confirmed the presence of ceftriaxone antibodies.

© 2009 Lippincott Williams & Wilkins, Inc.

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