A 4-year-old girl with PHACES syndrome (posterior fossa brain malformations, hemangiomas, arterial anomalies, cardiac anomalies/coarctation of the aorta, eye abnormalities, and sternal clefting/supraumbilical raphe) developed a cerebellar pilocytic astrocytoma 18 months after resolution of her neck, ear, and thoracic hemangiomas. Because cutaneous hemangiomas may have involuted by the time a patient is diagnosed with a central nervous system neoplasm, it seems possible that in other such patients the association may have gone unrecognized. Cerebellar pilocytic astrocytoma may be a rare manifestation of the posterior fossa malformations of PHACES.
*Divisions of Hematology Oncology
‡Departments of Pediatrics and Pathology/Laboratory Medicine, The University of North Carolina, Chapel Hill, NC
No financial support was received for the production of this case report.
Reprints: Katharine E. Wallen, MD, Division of Pediatric Hematology Oncology, Room 1106, 170 Manning Drive, University of North Carolina, Chapel Hill, NC 27599-7236 (e-mail: firstname.lastname@example.org).
Received for publication August 8, 2008; accepted November 18, 2008