Overgrowth syndromes such as Beckwith-Wiedemann syndrome, Sotos syndrome, and Weaver syndrome have an increased risk of neoplasia. Two previous cases of neuroblastoma have been reported in children with Weaver syndrome. We present a third description of a patient with Weaver syndrome and neuroblastoma. In a child with phenotypic characteristics consistent with Weaver syndrome, evaluation for neuroblastoma should be considered.
Divisions of *Hematology-Oncology
†Genetics and Metabolism, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC
Sources of Support: None.
Reprints: Don Coulter, MD, Division of Hematology-Oncology, Department of Pediatrics, University of North Carolina School of Medicine, 3315 Gravely Building, 130 Mason Farm Road, CB No. 7220, Chapel Hill, NC 27599-7220 (e-mail: email@example.com).
Received for publication December 11, 2007; accepted March 13, 2008