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Weaver Syndrome and Neuroblastoma

Coulter, Don MD*; Powell, Cynthia M. MD; Gold, Stuart MD*

Journal of Pediatric Hematology/Oncology: October 2008 - Volume 30 - Issue 10 - p 758-760
doi: 10.1097/MPH.0b013e3181758974
Clinical and Laboratory Observations

Overgrowth syndromes such as Beckwith-Wiedemann syndrome, Sotos syndrome, and Weaver syndrome have an increased risk of neoplasia. Two previous cases of neuroblastoma have been reported in children with Weaver syndrome. We present a third description of a patient with Weaver syndrome and neuroblastoma. In a child with phenotypic characteristics consistent with Weaver syndrome, evaluation for neuroblastoma should be considered.

Divisions of *Hematology-Oncology

Genetics and Metabolism, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC

Sources of Support: None.

Reprints: Don Coulter, MD, Division of Hematology-Oncology, Department of Pediatrics, University of North Carolina School of Medicine, 3315 Gravely Building, 130 Mason Farm Road, CB No. 7220, Chapel Hill, NC 27599-7220 (e-mail: dcoulter@unch.unc.edu).

Received for publication December 11, 2007; accepted March 13, 2008

© 2008 Lippincott Williams & Wilkins, Inc.