Skip Navigation LinksHome > July 2008 - Volume 30 - Issue 7 > Subcutaneous Panniculitislike T-cell Lymphoma With Hemophago...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31817588e8
Clinical and Laboratory Observations

Subcutaneous Panniculitislike T-cell Lymphoma With Hemophagocytosis: Complete Remission With BFM-90 Protocol

Medhi, Kunjahari MD, DM*; Kumar, Rajive MD; Rishi, Arvind MD; Kumar, Lalit MD, DM*; Bakhshi, Sameer MD*

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Subcutaneous panniculitislike T-cell lymphoma (SPTCL) is an uncommon type of cutaneous lymphoma. In many cases, SPTCL is accompanied by hemophagocytic syndrome (HPS), resulting in prominent systemic symptoms. The natural history, optimal treatment strategy, and prognostic factors associated with this malignancy are not well defined. We report an 11-year-old boy of SPTCL with HPS who was initially treated with conventional cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy, but progressed later on therapy. Subsequently, the child was treated with multiagent combination chemotherapy as per BFM-90 protocol and achieved complete remission, and has remained so for 3 years. This report suggests the value of this particular multiagent combination chemotherapy regimen in the treatment of patients with SPTCL and HPS.

© 2008 Lippincott Williams & Wilkins, Inc.


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