Skip Navigation LinksHome > July 2008 - Volume 30 - Issue 7 > Severe Neurotoxicities in a Case of Charcot-Marie-Tooth Dise...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31816624a4
Original Articles

Severe Neurotoxicities in a Case of Charcot-Marie-Tooth Disease Type 2 Caused by Vincristine for Acute Lymphoblastic Leukemia

Nishikawa, Takuro MD*; Kawakami, Kiyoshi MD*; Kumamoto, Takashi MD*; Tonooka, Shiro MD*; Abe, Akiko MD; Hayasaka, Kiyoshi MD; Okamoto, Yasuhiro MD; Kawano, Yoshifumi MD

Collapse Box

Abstract

We report a 13-year-old male patient with Charcot-Marie-Tooth disease (CMT) type 2 who developed severe neuropathy because of vincristine (VCR) for his acute lymphoblastic leukemia. A clumsy gait, muscle weakness in his fingers, and inverted champagne bottlelike muscle in the lower limbs were noticed after remission induction treatment for acute lymphoblastic leukemia, which included VCR at a total dose of 8 mg/m2. An electrophysiologic study showed an almost normal median motor nerve conduction velocity (approximately 50 m/s), markedly reduced M-wave amplitude and sensory disturbance. He was diagnosed as CMT type 2 based on his symptoms and electrophysiologic findings. His symptoms gradually worsened, and even after VCR was discontinued, he could not walk alone for 7 months. VCR has previously been considered to be relatively safe in CMT type 2, however, some patients with CMT type 2 might show severe neurologic toxicities, as seen in patients with CMT type 1.

© 2008 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us

Twitter
twitter.com/JPHOonline

For additional oncology content, visit LWW Oncology Journals on Facebook.