Skip Navigation LinksHome > July 2008 - Volume 30 - Issue 7 > Severe Neurotoxicities in a Case of Charcot-Marie-Tooth Dise...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31816624a4
Original Articles

Severe Neurotoxicities in a Case of Charcot-Marie-Tooth Disease Type 2 Caused by Vincristine for Acute Lymphoblastic Leukemia

Nishikawa, Takuro MD*; Kawakami, Kiyoshi MD*; Kumamoto, Takashi MD*; Tonooka, Shiro MD*; Abe, Akiko MD; Hayasaka, Kiyoshi MD; Okamoto, Yasuhiro MD; Kawano, Yoshifumi MD

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We report a 13-year-old male patient with Charcot-Marie-Tooth disease (CMT) type 2 who developed severe neuropathy because of vincristine (VCR) for his acute lymphoblastic leukemia. A clumsy gait, muscle weakness in his fingers, and inverted champagne bottlelike muscle in the lower limbs were noticed after remission induction treatment for acute lymphoblastic leukemia, which included VCR at a total dose of 8 mg/m2. An electrophysiologic study showed an almost normal median motor nerve conduction velocity (approximately 50 m/s), markedly reduced M-wave amplitude and sensory disturbance. He was diagnosed as CMT type 2 based on his symptoms and electrophysiologic findings. His symptoms gradually worsened, and even after VCR was discontinued, he could not walk alone for 7 months. VCR has previously been considered to be relatively safe in CMT type 2, however, some patients with CMT type 2 might show severe neurologic toxicities, as seen in patients with CMT type 1.

© 2008 Lippincott Williams & Wilkins, Inc.


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