The development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiation-associated synovial sarcomas are uncommon and exceedingly rare in pediatric patients. We report an unusual case of paraspinal synovial sarcoma presenting in an adolescent female 13 years after radiation therapy for her neuroblastoma.
Departments of *Pediatric Hematology/Oncology
†Pathology and Molecular Medicine
∥Diagnostic Radiology, McMaster University
§Department of Pediatric Hematology/Oncology, Hamilton Health Sciences, Hamilton, Ontario, Canada
Reprints: Dr Ali Mullah-Ali, FRCPC, Department of Pediatric Hematology/Oncology, Division of Pediatrics, McMaster University, Hamilton, Ontario, Canada (e-mail: firstname.lastname@example.org).
Received for publication June 27, 2007; accepted February 6, 2008