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Paraspinal Synovial Sarcoma as an Unusual Postradiation Complication in Pediatric Abdominal Neuroblastoma

Mullah-Ali, Ali FRCPC*; Ramsay, Jennifer A. MDCM, FRCP; Bourgeois, Jacqueline M. MSc, MD, FRCP; Hodson, Ian MA, BM, BCh, FRCPC; MacDonald, Paula BSc, Phm§; Midia, Mehran MD, FRCPC; Portwine, Carol MD, FRCPC, PhD*

Journal of Pediatric Hematology/Oncology: July 2008 - Volume 30 - Issue 7 - pp 553-557
doi: 10.1097/MPH.0b013e31816e22e3
Clinical and Laboratory Observations

The development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiation-associated synovial sarcomas are uncommon and exceedingly rare in pediatric patients. We report an unusual case of paraspinal synovial sarcoma presenting in an adolescent female 13 years after radiation therapy for her neuroblastoma.

Departments of *Pediatric Hematology/Oncology

Pathology and Molecular Medicine

Radiation Oncology

Diagnostic Radiology, McMaster University

§Department of Pediatric Hematology/Oncology, Hamilton Health Sciences, Hamilton, Ontario, Canada

Reprints: Dr Ali Mullah-Ali, FRCPC, Department of Pediatric Hematology/Oncology, Division of Pediatrics, McMaster University, Hamilton, Ontario, Canada (e-mail: mullah_ali@hotmail.com).

Received for publication June 27, 2007; accepted February 6, 2008

© 2008 Lippincott Williams & Wilkins, Inc.