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Metastatic Hepatic Epithelioid Hemangioendothelioma in a Teenage Girl

Kassam, Alisha BEng, MD*; Mandel, Karen MD, FRCPC

Journal of Pediatric Hematology/Oncology: July 2008 - Volume 30 - Issue 7 - pp 550-552
doi: 10.1097/MPH.0b013e31816e22d1
Clinical and Laboratory Observations

Hepatic epithelioid hemangioendothelioma (HEHE) is a rare malignant tumor characterized by its epithelioid structure and vascular endothelium origin. The clinical course of HEHE is variable, ranging from long-term survival without treatment to a rapidly progressive course with a fatal outcome. As a consequence, no standard treatment has been determined. We present a case of HEHE occurring in a 13-year-old girl, in which a novel treatment approach using antiangiogenic therapy was tried and was successful in slowing the progression of the disease.

*Faculty of Medicine, University of Ottawa, Ottawa, Ontario

Department of Pediatrics, Children's Hospital of Eastern Ontario, Canada.

Reprints: Karen Mandel, MD, FRCPC, Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada (e-mail: kmandel@cheo.on.ca).

Received for publication March 8, 2007; accepted February 1, 2008

© 2008 Lippincott Williams & Wilkins, Inc.