Hepatic epithelioid hemangioendothelioma (HEHE) is a rare malignant tumor characterized by its epithelioid structure and vascular endothelium origin. The clinical course of HEHE is variable, ranging from long-term survival without treatment to a rapidly progressive course with a fatal outcome. As a consequence, no standard treatment has been determined. We present a case of HEHE occurring in a 13-year-old girl, in which a novel treatment approach using antiangiogenic therapy was tried and was successful in slowing the progression of the disease.
*Faculty of Medicine, University of Ottawa, Ottawa, Ontario
†Department of Pediatrics, Children's Hospital of Eastern Ontario, Canada.
Reprints: Karen Mandel, MD, FRCPC, Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada (e-mail: firstname.lastname@example.org).
Received for publication March 8, 2007; accepted February 1, 2008