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A 13-year-old Girl With Cold Agglutinin Syndrome Caused by Anti-i

Mason, Holli M. MD*; Arndt, Patricia A. MSMT, MT(ASCP)SBB

Journal of Pediatric Hematology/Oncology: July 2008 - Volume 30 - Issue 7 - pp 543-545
doi: 10.1097/MPH.0b013e318161a9f9
Clinical and Laboratory Observations

A 13-year-old girl with cold agglutinin syndrome caused by anti-i was serologically positive for Epstein-Barr virus. The anti-i had a high titer at 4°C and high thermal amplitude (reacting up to 37°C with both cord i RBCs and the patient's autologous RBCs). The patient's hemoglobin dropped to 48 g/L. The age of the patient, the severity of the hemolysis, and the antibody specificity were unusual features of cold agglutinin syndrome. Transfusions with adult (I) red blood cells were effective.

*Transfusion Medicine and Serology, Harbor UCLA Medical Center, Torrance

American Red Cross Blood Services, Southern California Region, Pomona, CA

Reprints: Holli M. Mason, MD, Department of Transfusion Medicine and Serology, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509-2910 (e-mail: hmm_md@yahoo.com).

Received for publication June 5, 2007; accepted October 25, 2007

The authors have no financial relationships relevant to this article to disclose.

© 2008 Lippincott Williams & Wilkins, Inc.