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A 13-year-old Girl With Cold Agglutinin Syndrome Caused by Anti-i

Mason, Holli M. MD*; Arndt, Patricia A. MSMT, MT(ASCP)SBB

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318161a9f9
Clinical and Laboratory Observations

A 13-year-old girl with cold agglutinin syndrome caused by anti-i was serologically positive for Epstein-Barr virus. The anti-i had a high titer at 4°C and high thermal amplitude (reacting up to 37°C with both cord i RBCs and the patient's autologous RBCs). The patient's hemoglobin dropped to 48 g/L. The age of the patient, the severity of the hemolysis, and the antibody specificity were unusual features of cold agglutinin syndrome. Transfusions with adult (I) red blood cells were effective.

Author Information

*Transfusion Medicine and Serology, Harbor UCLA Medical Center, Torrance

American Red Cross Blood Services, Southern California Region, Pomona, CA

Reprints: Holli M. Mason, MD, Department of Transfusion Medicine and Serology, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509-2910 (e-mail:

Received for publication June 5, 2007; accepted October 25, 2007

The authors have no financial relationships relevant to this article to disclose.

© 2008 Lippincott Williams & Wilkins, Inc.