A 13-year-old girl with cold agglutinin syndrome caused by anti-i was serologically positive for Epstein-Barr virus. The anti-i had a high titer at 4°C and high thermal amplitude (reacting up to 37°C with both cord i RBCs and the patient's autologous RBCs). The patient's hemoglobin dropped to 48 g/L. The age of the patient, the severity of the hemolysis, and the antibody specificity were unusual features of cold agglutinin syndrome. Transfusions with adult (I) red blood cells were effective.
*Transfusion Medicine and Serology, Harbor UCLA Medical Center, Torrance
†American Red Cross Blood Services, Southern California Region, Pomona, CA
Reprints: Holli M. Mason, MD, Department of Transfusion Medicine and Serology, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509-2910 (e-mail: firstname.lastname@example.org).
Received for publication June 5, 2007; accepted October 25, 2007
The authors have no financial relationships relevant to this article to disclose.