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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318169167b
Clinical and Laboratory Observations

Prolonged Survival With Continuous Infusion Topotecan: A Report of 2 Cases

Klopfenstein, Kathryn J. MD*; Scott, Suzanne RN, MS, CPNP; Schuller, David E. MD; Ruymann, Frederick B. MD

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Abstract

Two patients with solid tumors were treated with 21-day continuous infusion topotecan as palliation therapy. Case 1: A 10-year-old girl was diagnosed with progressive, metastatic hepatocellular carcinoma. Twenty-one–day continuous infusion topotecan was started and she has had a partial response. Case 2: A 17-year-old girl developed a malignant fibrous histiocytoma as a second malignant neoplasm. After partial resection and failure of multiagent chemotherapy, she started continuous infusion topotecan and was disease-free for 58 months when she died of pneumonia. These cases suggest that topotecan given as 21-day continuous infusion is efficacious for palliation care.

© 2008 Lippincott Williams & Wilkins, Inc.

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