POEMS syndrome is a rare multisystem disorder, which is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. We report a 15-year-old girl with POEMS syndrome, who developed growth retardation, delayed puberty, gradually increasing abdominal distention, brown skin pigmentation, hypogonadism, hepatosplenomegaly, lympadenomegaly, monoclonal gammopathy, and anemia. The patient dramatically responded to pulse steroid therapy. To our knowledge, this patient is one of the youngest reported cases of POEMS syndrome.
*Department of Pediatrics, Bakirkoy Dr. Sadi Konuk Research and Training Hospital
†Department of Pediatric Hematology Oncology, Istanbul University, Institute of Oncology
‡Department of Pathology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkiye
Reprints: Esra Sevketoglu, MD, Department of Pediatrics, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkiye (e-mail: firstname.lastname@example.org).
Received for publication August 15, 2007; accepted October 20, 2007