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Using QuantiFERON-TB Gold In-Tube for Field-Based Tuberculosis Contact Investigations in Congregate Settings

Trieu, Lisa MPH; Proops, Douglas C. MD, MPH; Ahuja, Shama D. PhD, MPH

Journal of Public Health Management & Practice: May/June 2013 - Volume 19 - Issue 3 - p E11–E13
doi: 10.1097/PHH.0b013e318268af0b
Original Articles

Contact investigations are crucial to controlling tuberculosis in the United States. In these investigations, the tuberculin skin test has been the primary test to detect tuberculosis infection. Interferon-γ release assays, such as the QuantiFERON-TB Gold In-Tube test, were recently introduced and are intended to address limitations of the tuberculin skin test. However, there are limited data on the use of these tests in contact investigations in congregate settings. We present 2 field-based investigations to highlight potential advantages, limitations, and feasibility of using the QuantiFERON-TB Gold In-Tube test in congregate setting investigations.

This article discusses 2 New York City contact investigations that used the QuantiFERON-TB Gold In-Tube (QFT-GIT) test in noninstitutional congregate settings and highlights potential advantages, limitations, and feasibility of using the QFT-GIT test for field-based contact investigations among foreign-born, hard-to-reach, and transient populations.

New York City Department of Health and Mental Hygiene, Bureau of Tuberculosis Control, New York.

Correspondence: Lisa Trieu, MPH, New York City Department of Health and Mental Hygiene, Bureau of Tuberculosis Control, Gotham Center, 42-09, 28th St, 21st Floor, CN-72B, WS 21-10, Long Island City, NY 11101 (ltrieu@health.nyc.gov).

All authors substantially contributed to the drafting, editing, or review of this article. The New York City Department of Health and Mental Hygiene, Bureau of Tuberculosis Control, has received grants from Qiagen Inc to support select contact investigations. No grants were received for the investigations described.

The authors declare no conflicts of interest.

© 2013 Lippincott Williams & Wilkins, Inc.