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Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men

Ott, Christian; Schneider, Markus P.; Delles, Christian; Schlaich, Markus P.; Hilgers, Karl F.; Schmieder, Roland E.

Pharmacogenetics and Genomics: June 2011 - Volume 21 - Issue 6 - p 347–349
doi: 10.1097/FPC.0b013e328344cdd2
Short Communications

The renin–angiotensin system is a major regulatory system of cardiovascular and renal function. Recently, (pro)renin receptor [(P)RR] was identified as new component of the renin–angiotensin system. The IVS5+169C>T polymorphism of the (P)RR gene was shown to be associated with blood pressure (BP) in Japanese men, but no data are available for Caucasians. Hence, we genotyped the IVS5+169C>T polymorphism of the (P)RR gene in 266 Caucasian men with normal or mildly elevated BP and without any medication. Office BP was measured according to current guidelines. Office and resting systolic BP was lower in C-allele than in T-allele carriers (P<0.05) of the (P)RR gene, with no difference in diastolic BP and heart rate. Serum aldosterone was also lower in C-allele than in T-allele carriers (P<0.05). These findings indicate that C-allele carriers have lower systolic BP than T-allele carriers. Thus, our data suggest that (P)RR influences BP regulation in Caucasian men, potentially through altered aldosterone release.

Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany

Correspondence to Dr Roland E. Schmieder, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Krankenhausstrasse 12, Erlangen 91054, Germany Tel: +49 9131 853 6245; fax: +49 9131 853 9209; e-mail: roland.schmieder@uk-erlangen.de

Received May 10, 2010

Accepted January 19, 2011

Copyright © 2011 Wolters Kluwer Health, Inc. All rights reserved.