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Skip Navigation LinksHome > November 2010 - Volume 51 - Issue 5 > Regulatory T Cells and T Helper Subsets in Breast-fed Infant...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e3181e85b22
Short Communications

Regulatory T Cells and T Helper Subsets in Breast-fed Infants With Hematochezia Caused by Allergic Colitis

Cseh, Áron*; Molnár, Kriszta; Pintér, Petra; Szalay, Balazs*; Szebeni, Beata*; Treszl, Andras*; Arató, Andras; Vásárhelyi, Barna*; Veres, Gabor

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Abstract

The objective of our study was to investigate the prevalence of CD4+ T lymphocyte subsets and their commitment to TH1 or TH2 direction in 10 infants with allergic colitis (AC) and 10 healthy controls. Infants with AC presented with a higher ratio of naïve to memory cells, lower prevalence of activated CD4+CD25+ cells and FoxP3+ regulatory cells, and a shift to TH2 direction in balance compared with controls. These alterations are normalized upon cessation of AC symptoms on elemental L-amino acid formula. These findings suggest the importance of antigen exposure in AC in infancy.

Copyright 2010 by ESPGHAN and NASPGHAN

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