Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
You currently have no recent searches
Bhat, Abdus S.; Varma, Sharat; Chaturvedi, Mona K.
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
To the Editor:
A 12-year-old boy from north India with a history of ventricular septal defect repair at 1 year of age was diagnosed as having chronic hepatitis C, genotype 3. After initial evaluation and a liver biopsy, he started taking pegylated interferon α-2b (PEGIFNα-2b) at a dose of 60 μg/m2 subcutaneously weekly and ribavarin at a dose of 15 mg · kg−1 · day−1(1,2). At 12 weeks of therapy, his hepatitis C virus RNA was below detectable limits but had again appeared at 24 weeks, so he was continued on the said treatment. He was tolerating the treatment well; however, in the 28th week of the PEGIFNα-2b, after 3 hours of the injection, while playing in the field, he fell unconscious and was brought to the hospital after 15 minutes in cardiorespiratory arrest. He was revived after cardiopulmonary resuscitation. There were no features of acute hypersensitivity; electrolytes, calcium, and blood sugar were normal. Computed tomography scan of brain was normal. His electrocardiogram taken later on was normal. After 1 month of the event, he is still in the hospital, on ventilator. Magnetic resonance imaging of brain showed features of severe hypoxia.
We consider this whole event as a possible adverse effect of PEGIFN administration, although we do not have clarity about the nature of the terminal event, possibly seizure or arrhythmia. Seizures have been reported with PEGIFN in adults, but all of them had comorbidities to explain seizures (3). Arrhythmias have not been reported with PEGIFNα in children and it has been used successfully in patients with coexisting heart disease (4). No deaths have been reported in children.
Copyright 2012 by ESPGHAN and NASPGHAN
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Journal of Pediatric Gastroenterology and Nutrition.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Visit JPGN.org on your smartphone. Scan this code (QR reader app required) with your phone and be taken directly to the site.