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Halac, Ugur; Lacaille, Florence; Joly, Francisca; Hugot, Jean-Pierre; Talbotec, Cécile; Colomb, Virginie; Ruemmele, Frank; Goulet, Olivier
Pediatric Gastroenterology, Hepatology and Nutrition Unit, Necker-Enfants Malades, Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
To the Editor: Diamanti et al (1) provide an interesting observation of 4 children with zinc and/or copper deficiencies associated with acrodermatitis enteropathica–like rash in 3 and macrocytic anemia and neutropenia in 1 patient with microvillus inclusion disease. Our report represents a large group of 24 European children who were referred to our center during a 14-year period with this rare and severe autosomal recessive disorder (2). A limitation of our retrospective study is that analyses of blood trace element and mineral levels were not available; however, all of our patients received standard parenteral supplementation of minerals and trace elements (3), and none had any reports of dermatologic features during follow-up. Despite the small number of patients in Diamanti et al's report, this information is clinically relevant. Providers caring for patients with microvillus inclusion disease need to heed this important message.
Copyright 2012 by ESPGHAN and NASPGHAN
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