VALIDATION OF A SECOND-GENERATION GI SYMPTOM ASSESSMENT INSTRUMENT TO DETERMINE GASTRITIS AND THE PRESENCE OF H. PYLORI IN CHILDRENSnyder, John D.1; Gold, Benjamin D.2; Chen, Yunn-Yi3; Czinn, Steven4; Perrin, James M.5Journal of Pediatric Gastroenterology & Nutrition: October 2006 - Volume 43 - Issue 4 - p E27 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, October 19-22, 2006, Orlando, Florida: Abstracts: POSTER SESSION I, THURSDAY, OCTOBER 19, 2006, 5 p.m. - 7 p.m.: Esophagus/Stomach: 42 Author Information Article Outline 1Pediatrics, UCSF, San Francisco, CA; 2Pediatrics, Emory, Atlanta, GA; 3Pathology, UCSF, San Francisco, CA; 4Pediatrics, Case Western University, Cleveland, OH; 5Pediatrics, Children's Hospital, Boston, MA. Background: Methods: Results: Conclusions: Back to Top | Article Outline Background: Previous studies have shown poor correlation between signs and symptoms of abdominal pain and the presence of H. pylori in children. However, these studies were carried out before the development of validated pediatric GI symptom assessment instruments (SAI). We evaluated the predictive value of a second generation SAI to determine the presence and severity of gastritis and correlation with H. pylori infection. Back to Top | Article Outline Methods: We enrolled symptomatic children who required endoscopy (EGD) and biopsy. Before EGD, an SAI (0-5 severity scale) was completed by the child and/or their parent. A GI pathologist evaluated each biopsy specimen using the updated Sydney System. H. pylori was diagnosed by histology and a rapid diagnostic urease test. Back to Top | Article Outline Results: 49 children were evaluated over a 2-year period. Gastritis was found in 21 patients (43%), including 4 (8%) with H. pylori. Moderate or severe gastritis was found in 38% of those with inflammation, including all 4 with H. pylori. SAI findings are summarized in the Table 1. The severity of chest pain, burping and regurgitation in the H. pylori patients was more than twice that of the other 2 groups. However, the small cohort size to date precludes determination of statistically significant differences. Back to Top | Article Outline Conclusions: Our preliminary data indicate that the SAI may be useful in distinguishing children with H. pylori infection from those with no gastritis or those with non-H. pylori inflammation. Enrollment to obtain a sufficiently powered patient population is ongoing.Table 1© 2006 Lippincott Williams & Wilkins, Inc.