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Journal of Pediatric Gastroenterology & Nutrition:
ABSTRACTS: Poster Session Abstracts

P0878 SPECIFIC HISTOLOGICAL FINDINGS EXIST IN DIGESTIVE MUCOSA IN AUTISTIC CHILDREN WITH GASTROINTESTINAL SYMPTOMS?

González, L. G.1; López, K. K. L.1; Martínez, M. M. M.1; Navarro, D. D. N.1; Negrón, L. L. N.1; Rodríguez, R. R. R.1; Villalobos, D. D. V.1

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1Pediatric Gastroenterology, Dr. Miguel Pérez Carreño Hospital, Caracas, Venezuela

Submitted by: gordygordy26@hotmail.com

Introduction: Autistic children develop gastrointestinal symptoms, recent studies evaluated the function and structure of the mucosal gut in children with autistc disorders.

Methods: We study 45/75 autistic children. All the patients we accomplished clinic history, physical exploration, laboratory test, upper gastrointestinal endoscopy and colonoscopy. Biopsies were obtained from mucosa esophagus, stomach, duodenun and colon. and compared with biopsies of children without autism (control group). Statistical analysis mean + SD, X, X2 test, significance p<0.05

Results: Fourty five autistic children (13 girls and 42 boys); mean age 1,98 + 1,37 years (18m-12years). Gastrointestinal symptoms: vomiting 44,44%, chronic diarrea 35,55%, constipation and spittle both 33,33%. We not found specific histological finding between the groups p0.05. In contrast, the histological diagnosis most frecuently detected in autistic children were reflux esophagitis (88,88%) and chronic active gastritis with lympho-nodular hyperplasia by Helicobacter pylori (55,56%), a difference between group p <0.001 and p<001 respectively. No there wasn’t differencies in duodenum and colon. Lymphonodular hyperplasia was seen in 39 autistic children with chronic active duodenitis, in 23/39 we detected Giardia intestinalis infecction. We found association between lymphonodular hyperplasia and Helicobacter pylori or Giardia infection p<0.002. The chronic active colitis with lymphonodular hyperplasia for food allergies occurred in 68,89% autistic children.

Conclusion: The histological changes are not specific of autistic children. We suggest that lymphonodular hyperplasia is a specific finding local reactivity in children with infeccion and food allergy independient condition of autism. We conclude that all autistic children should be evaluated carefully for high incidence gastrointestinal desease found in this study.

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Reference(S):

1.-American Psichiatric Asotiation. Diagnostic d statistical manual of mental disorders. 4th ed. Washington (DC): . American Psiyhiatric Asotiation: 1994
2.-Karoly Hovarth, John Papadimitiou, Anna R, Cinthia D., et al. Gastrointestinal abnormalities in children with autisitc disorders. J of Pediatr 1999;135:559–63.
3.-Corri Black., James A., Kaye., Hershel J.Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Data-base.BMJ 2002;325:419–21.
4.-Eamonn M Quigley., Autism and Gastrotestinal Tract. AJG 2000; 9:2154–56.
5.-Wakefield AJ., Murch SH., Anthony A., et al. Ileal lymphoid nodular hyperplasia, non especific colitis and pervasive disorder in children. Lancet 1998;351:637–41.

© 2004 Lippincott Williams & Wilkins, Inc.

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