Campoy, C.1; Marchal, G.2; Decsi, T.3; Cruz, M.2; Szabo, E.3; Demmelmair, H.4; Rodríguez, M.5; Rivero, M.5; Koletzko, B.4

Journal of Pediatric Gastroenterology & Nutrition: June 2004 - Volume 39 - Issue - p S11
ABSTRACTS: Oral Presentation Abstracts

1Paediatrics, 2Obstetric and Gynecology, School of Medicine. University of Granada, Granada, Spain, 3Paediatrics, University of Pécs, Pécs, Hungary, 4Paediatrics, Dr. v. Haunersches Kinderspital, LMU, München, Germany, 5Scientific Department, Ordesa Laboratories, Barcelona, Spain

Submitted by: ccampoy@ugr.es

Introduction: The foetal accretion of LC-PUFAs depend on mother’s stores, dietary intake and endogenous synthesis of LC-PUFAs. Recently, it has been demonstrated that placental tissue has a preferential metabolic pathway to transfer DHA from the mother to the foetus, in comparison with linoleic, oleic or palmitic acids. The aim of this study is to analyse if different nutritional supplements during pregnancy enhance the neonate nutritional status of DHA.

Methods: A total of 153 Spanish healthy pregnant women participants in the NUHEAL study; aged between 18 and 40 years, were recruited at the 20±1 wks of gestation. Following a double blind & random design, were subdivided into 4 groups, depending on the supplement received until delivery (DHA: 0.5 g/day; 5-MTHF: 0.4 mg/day; both or placebo). Plasma phospholipid FA were measured by gas chromatography. ANOVA, General lineal model with repeated measures & correlation study were performed using SPSS Versions 11.5.

Results: The groups 1 & 4 showed higher concentrations of plasma phospholipid DHA & lower ratios n-6/n3 & AA/DHA, in the 30th & at delivery than groups 2 and 3 (a, b). The groups 1 and 4 showed an increment of DHA between 20th and 30th, but not between 30th wks & delivery. The groups 2 and 3 didn’t show any change from 20th wks until delivery(*,#). No changes in plasma phospholipid AA were observed in all groups, even in the neonates. Mother-neonate significant correlations were established (DHA: r: 0.30, p=0.0028; AA/DHA: r:−0.43, p<0.00001). The only n-3 PUFA found in umbilical cord was DHA.

Conclusion: There is significant differences between the groups studied, and depending on the supplement received there is an increase of plasma phospholipid DHA in mother & infant, without modifications in AA levels. n-6/n-3 & AA/DHA ratios were lower in the groups 1 and 4. The reason of these results will be explained after the study finish the present unblended situation.

The preferential placental mechanism for transferring DHA from mother to the foetus is indirectly suggested.

© 2004 Lippincott Williams & Wilkins, Inc.