Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Henker, J.; Soldan, W.; Sprössig, C.
Children's Hospital, University of Technology Dresden, Germany
The determination of fecal concentration of pancreatic elastase 1 (E1) has recently been described as a valuable parameter for estimation of exocrine pancreatic function (Scheefers-Borchel U et al. Lab med 1992;16:427). The aim of our study was the comparison of the E1 concentration in feces with the results of sekretin-pancreozymin-test in CF-patients.
Material and Methods: Sensitivity of fecal E1 concentration was determined in 16 CF-patients (median of age 17.3 yr) on pancreatic enzyme replacement therapy. Specificity was assessed in 23 healthy children (median of age 5.7 yr). Fecal E1 was determined with an ELISA based on two monoclonal antibodies against human Elastase 1 (Schebo•Tech GmbH, Wettenberg, Germany). Aliquots of a homogenized 24h-stool-collection were tested. Pancreatic function was classified according to fecal E1 concentration as follows: Table
Results and conclusion: According to secretin-pancreozymin-test 15 of the 16 investigated CF-patients had a severe pancreatic insufficiency and only 1 patient was moderately insufficient. The determination of fecal E1 concentration had a sensitivity to (severe) pancreatic insufficiency of 100% and a specificity of 96%. E1 determination in stool seems to be a more sensitive and specific test for pancreatic insufficiency than other indirect tube-less tests. Moreover, pancreatic function can be assessed without interruption of pancreatic enzyme therapy.
Munich, June 5-8, 1996
© Lippincott-Raven Publishers
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Journal of Pediatric Gastroenterology and Nutrition.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics