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Horvath, K.; Lebenthal, E.*
Department of Pediatrics, University of Maryland, Baltimore, Maryland *International Institute for Infant Nutrition and Gastrointestinal Disease, Department of Pediatrics, Hadassah-Hebrew University, Mount Scopus, Jerusalem, Israel.
Short polymers of Glucose (G2-9) are absorbed faster than D-glucose in the small intestine and reverse the intestinal secretion induced by dibutyryl cyclic AMP. We studied a possible sodium coupled short polymer of glucose transport in the small intestine. We compared the sodium absorption in isomolar glucose and isomolar glucose and glucose polymer solutions (GP-5, GP-6 and GP-7) in brush border membrane vesicles, isolated intestinal epithelial cells and monolayer of intestinal epithelial cells (Caco-2 cells). In brush border membrane vesicles kinetic study and overshoot uptake study were done in the absence and presence of acarbose. The short-term (10 seconds) uptake of sodium was significantly higher from isosmotic GP-5 solution at concentration 25 and 50 mM, in the presence of different concentration of sodium. We demonstrated a higher sodium and glucose accumulation in isolated cells using 25 mM GP-5 compared with that of D-glucose. In fluorescent studies a rapid increase in intracellular sodium content was shown from both GP-6 and GP-7 solutions compared to D-glucose. Caco-2 cells after reaching the monolayer stage showed a higher sodium transport from both 25 and 100 mM solutions of glucose polymers compared to those of isomolar glucose solutions. Furthermore, inhibition of maltase and glucoamylase with acarbose did not decrease the transepithelial sodium transport in a solution containing GPs. In Conclusion there is a higher sodium uptake from isosmotic and isomolar short-polymers of glucose solution in brush border membrane vesicles, isolated cells and in monolayer of epithelial cells compared to those containing D-glucose.
Munich, June 5-8, 1996
© Lippincott-Raven Publishers
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