Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
You currently have no recent searches
Horvath, K.; Lebenthal, E.*
Department of Pediatrics, University of Maryland, Baltimore, Maryland *International Institute for Infant Nutrition and Gastrointestinal Disease, Department of Pediatrics, Hadassah-Hebrew University, Mount Scopus, Jerusalem, Israel.
Short polymers of Glucose (G2-9) are absorbed faster than D-glucose in the small intestine and reverse the intestinal secretion induced by dibutyryl cyclic AMP. We studied a possible sodium coupled short polymer of glucose transport in the small intestine. We compared the sodium absorption in isomolar glucose and isomolar glucose and glucose polymer solutions (GP-5, GP-6 and GP-7) in brush border membrane vesicles, isolated intestinal epithelial cells and monolayer of intestinal epithelial cells (Caco-2 cells). In brush border membrane vesicles kinetic study and overshoot uptake study were done in the absence and presence of acarbose. The short-term (10 seconds) uptake of sodium was significantly higher from isosmotic GP-5 solution at concentration 25 and 50 mM, in the presence of different concentration of sodium. We demonstrated a higher sodium and glucose accumulation in isolated cells using 25 mM GP-5 compared with that of D-glucose. In fluorescent studies a rapid increase in intracellular sodium content was shown from both GP-6 and GP-7 solutions compared to D-glucose. Caco-2 cells after reaching the monolayer stage showed a higher sodium transport from both 25 and 100 mM solutions of glucose polymers compared to those of isomolar glucose solutions. Furthermore, inhibition of maltase and glucoamylase with acarbose did not decrease the transepithelial sodium transport in a solution containing GPs. In Conclusion there is a higher sodium uptake from isosmotic and isomolar short-polymers of glucose solution in brush border membrane vesicles, isolated cells and in monolayer of epithelial cells compared to those containing D-glucose.
Munich, June 5-8, 1996
© Lippincott-Raven Publishers
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Journal of Pediatric Gastroenterology and Nutrition.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Visit JPGN.org on your smartphone. Scan this code (QR reader app required) with your phone and be taken directly to the site.