Skip Navigation LinksHome > Published Ahead-of-Print > Topical Mitomycin-C Application in Recurrent Esophageal Stri...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0000000000000352
Original Article: Gastroenterology: PDF Only

Topical Mitomycin-C Application in Recurrent Esophageal Strictures After Surgical Repair of Esophageal Atresia.

Chapuy, Laurence; Pomerleau, Martine; Faure, Christophe

Published Ahead-of-Print
Collapse Box


Background and Aims: The aim of this study was to evaluate the efficacy and short term safety of topical mitomycin-C, an antifibrotic agent, in preventing the recurrence of anastomotic strictures after surgical repair of esophageal atresia (EA).

Patients and Methods: We retrospectively reviewed the medical records of patients with recurrent anastomotic strictures after EA surgery who underwent at least 3 esophageal dilations. We compared the outcome (i.e. resolution of the stricture) of the group that received topical mitomycin-C treatment with endoscopic esophageal dilation to a historical cohort treated by dilations alone.

Results: Eleven children received mitomycin-C concurrently with endoscopic dilations. After a median follow-up of 33 months (range 18-72), and a mean number of 5.4 dilations/patient (range 3-11), 8 out of 11 patients achieved a resolution of their stricture, 2 patients remained with stenosis and 1 patient needed a surgical correction. In the control group, 10 patients required an average of 3.7 (range 3-7) total dilations. After a follow-up of 125 months (range 35-266) after the last dilation, 9 out of 10 children had a disappearance of their stricture and the remaining patient was symptom free. No dysplasia related to mitomycin-C was demonstrated.

Conclusion: There is no benefit in the resolution of the stricture when adding mitomycin-C treatment compared to repeated esophageal dilations alone in historical controls. Further randomized controlled studies are needed as well as a short and long term evaluation of safety.

(C) 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,


Article Tools


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us





Visit on your smartphone. Scan this code (QR reader app required) with your phone and be taken directly to the site.