Institutional members access full text with Ovid®

Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents

Famouri, Fatemeh; Shariat, Zainab; Hashemipour, Mahin; Keikha, Mojtaba; Kelishadi, Roya

Journal of Pediatric Gastroenterology & Nutrition: March 2017 - Volume 64 - Issue 3 - p 413–417
doi: 10.1097/MPG.0000000000001422
Original Articles: Hepatology

Objectives: This study aims to evaluate the effects of some probiotics on sonographic and biochemical nonalcoholic fatty liver disease (NAFLD).

Methods: This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule (containing Lactobacillus acidophilus ATCC B3208, 3 × 109 colony forming units [CFU]; Bifidobacterium lactis DSMZ 32269, 6 × 109 CFU; Bifidobacterium bifidum ATCC SD6576, 2 × 109 CFU; Lactobacillus rhamnosus DSMZ 21690, 2 × 109 CFU) or placebo for 12 weeks.

Results: After intervention, in the probiotic group the mean levels of alanine aminotransferase decreased from 32.8 (19.6) to 23.1 (9.9) U/L (P = 0.02) and mean aspartate aminotransferase decreased from 32.2 (15.7) to 24.3 (7.7) U/L (P = 0.02). Likewise the mean cholesterol, low-density lipoprotein-C, and triglycerides as well as waist circumference decreased in the intervention group, without significant change in weight, body mass index, and body mass index z score. After the trial, normal liver sonography was reported in 17 (53.1%) and 5 (16.5%) of patients in the intervention and placebo groups, respectively.

Conclusions: The present findings suggest that a course of the abovementioned probiotic compound can be effective in improving pediatric NAFLD.

Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Address correspondence and reprint requests to Roya Kelishadi, MD, Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Hezarjerib Ave, Isfahan, Iran (e-mail: kelishadi@med.mui.ac.ir).

Received 6 July, 2015

Accepted 25 September, 2016

The study was conducted as a part of a thesis, funded by Isfahan University of Medical Sciences.

The authors report no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.jpgn.org).

© 2017 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,