Skip Navigation LinksHome > June 2014 - Volume 58 - Issue 6 > Does Infliximab Prevent Colectomy in Acute and Chronic Activ...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0000000000000340
Original Articles: Gastroenterology

Does Infliximab Prevent Colectomy in Acute and Chronic Active Ulcerative Colitis?

Dan-Nielsen, Steffen*; Wewer, Vibeke*; Paerregaard, Anders*; Hansen, Lars F.*; Nielsen, Rasmus G.; Lange, Aksel; Jakobsen, Christian*

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Abstract

Objectives: The aim of the study was to evaluate clinical response, use of colectomy, and adverse events related to infliximab (IFX) treatment in acute and chronic active ulcerative colitis (UC) in children.

Methods: Children from 3 centers, who had received IFX for UC, were identified, and patient charts were reviewed retrospectively. Data concerning symptoms, biochemistry, concomitant medical treatment, colectomy, and adverse events were registered.

Results: A total of 45 patients with UC (median age at diagnosis 12 years, interquartile range 10–14) were included, and studied for a median of 15 months (interquartile range 4.5–29) after first IFX infusion. The cumulative 1- and 2-year risks of colectomy were 21% and 26%, respectively. The cumulative 1- and 2-year risks of receiving a new course of systemic corticosteroids were 32% and 48%, respectively. Twenty-one patients (46%) experienced adverse events. Most common were mild infusion reactions, but 3 (7%) had serious adverse events.

Conclusions: IFX was efficient in preventing colectomy in children with UC. The risk of receiving systemic corticosteroids was lower than that reported in other studies. Most adverse events were mild to moderate and self-limiting.

© 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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