Skip Navigation LinksHome > May 2014 - Volume 58 - Issue 5 > Hydrolyzed Formulas for Allergy Prevention
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0000000000000318
Invited Reviews

Hydrolyzed Formulas for Allergy Prevention

Vandenplas, Yvan*; Bhatia, Jatinder; Shamir, Raanan; Agostoni, Carlo§; Turck, Dominique||; Staiano, Annamaria; Szajewska, Hania#

Supplemental Author Material
Continued Medical Education
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Objectives: The aim of the present review was to provide recommendations on the use of hydrolysates in infants when formula feeding is initiated.

Methods: We performed an overview of reviews followed by a systematic review of subsequently published trials.

Results: We found 8 systematic reviews; only 1 study of limited quality was published afterwards. Certain extensively hydrolyzed casein and certain partially hydrolyzed whey formulas are appropriate for reducing the risk of allergy in infants at high risk when formula feeding is initiated.

Conclusions: In high-risk infants, when breast-feeding is not possible, hydrolysates of documented safety and efficacy have an indication in infant feeding up to the age 4 to 6 months.

© 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,


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