We evaluated the effect of propofol on resting anal sphincter pressure (RP) during anorectal manometry performed under general anesthesia in 20 children with chronic constipation. After propofol bolus administration, there was a significant decrease in the RP in 95% of children from a mean of 51.5 ± 15.3 to a mean nadir of 21.7 ± 10.5 mmHg (P < 0.001). The new postpropofol RP of 47.0 ± 12.4 mmHg was significantly lower compared with prepropofol RP (P < 0.0001). Propofol should be used with caution as an anesthetic agent for anorectal manometry, given the potential for confounding RP measurements.
*Department of Pediatric Gastroenterology, New England Medical Center
†Gastroenterology Unit, Massachusetts General Hospital
‡Department of Anesthesia
§Division of Gastroenterology, Hepatology, and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston.
Address correspondence and reprint requests to Jaime Belkind-Gerson, MD, MS, Division of Gastroenterology, Hepatology, and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, 175 Cambridge St, 5th Floor, Boston, MA 02114 (e-mail: email@example.com).
Received 25 July, 2013
Accepted 25 September, 2013
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www.clinicaltrials.gov registration no.: NCT01793753.
The authors report no conflicts of interest.