Skip Navigation LinksHome > April 2014 - Volume 58 - Issue 4 > Effect of Propofol on Anal Sphincter Pressure During Anorect...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0000000000000190
Original Articles: Gastroenterology

Effect of Propofol on Anal Sphincter Pressure During Anorectal Manometry

Tran, Khoa*; Kuo, Brad; Zibaitis, Audrius; Bhattacharya, Somaletha; Cote, Charles; Belkind-Gerson, Jaime§

Continued Medical Education
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ABSTRACT: We evaluated the effect of propofol on resting anal sphincter pressure (RP) during anorectal manometry performed under general anesthesia in 20 children with chronic constipation. After propofol bolus administration, there was a significant decrease in the RP in 95% of children from a mean of 51.5 ± 15.3 to a mean nadir of 21.7 ± 10.5 mmHg (P < 0.001). The new postpropofol RP of 47.0 ± 12.4 mmHg was significantly lower compared with prepropofol RP (P < 0.0001). Propofol should be used with caution as an anesthetic agent for anorectal manometry, given the potential for confounding RP measurements.

© 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,


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