Effect of Propofol on Anal Sphincter Pressure During Anorectal Manometry

Tran, Khoa*; Kuo, Brad; Zibaitis, Audrius; Bhattacharya, Somaletha; Cote, Charles; Belkind-Gerson, Jaime§

Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0000000000000190
Original Articles: Gastroenterology
Abstract

ABSTRACT: We evaluated the effect of propofol on resting anal sphincter pressure (RP) during anorectal manometry performed under general anesthesia in 20 children with chronic constipation. After propofol bolus administration, there was a significant decrease in the RP in 95% of children from a mean of 51.5 ± 15.3 to a mean nadir of 21.7 ± 10.5 mmHg (P < 0.001). The new postpropofol RP of 47.0 ± 12.4 mmHg was significantly lower compared with prepropofol RP (P < 0.0001). Propofol should be used with caution as an anesthetic agent for anorectal manometry, given the potential for confounding RP measurements.

Author Information

*Department of Pediatric Gastroenterology, New England Medical Center

Gastroenterology Unit, Massachusetts General Hospital

Department of Anesthesia

§Division of Gastroenterology, Hepatology, and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston.

Address correspondence and reprint requests to Jaime Belkind-Gerson, MD, MS, Division of Gastroenterology, Hepatology, and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, 175 Cambridge St, 5th Floor, Boston, MA 02114 (e-mail: jbelkindgerson@mgh.harvard.edu).

Received 25 July, 2013

Accepted 25 September, 2013

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www.clinicaltrials.gov registration no.: NCT01793753.

The authors report no conflicts of interest.

© 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,