Objectives: The aim of the study was to determine whether intravenous fluid administration is independently associated with a reduction in unscheduled emergency department (ED) revisits within 7 days.
Methods: We conducted a single-center, retrospective observational cohort study in a pediatric ED in Toronto, Canada. Participants were younger than 18 years, diagnosed as having gastroenteritis, and discharged home between July 2003 and June 2008. Multivariable regression models were used to determine the associations between the exposures (intravenous rehydration, triage severity score, age) and ED revisits and revisits with intravenous rehydration. Accuracy was assessed using bootstrap analysis.
Results: There were 22,125 potentially eligible visits; 3346 were included in our final cohort. A total of 497 children (15%) received intravenous rehydration and 543 (16%) had an unscheduled revisit. Regression analysis included 2874 children with complete data, and identified 5 independent predictors of an ED revisit: intravenous rehydration (odds ratio [OR] 1.76; 95% confidence interval [CI] 1.36–2.26); number of vomiting episodes (1.20; 95% CI 1.04–1.28/5 episode increase); days of diarrhea (OR 0.92; 95% CI 0.88–0.97/day increase); frequency of diarrhea (1.19; 95% CI 1.03–1.38/5 episode increase); and age (OR 0.94; 95% CI 0.91–0.98/year). Bootstrap methodology identified intravenous rehydration, age, number of vomiting episodes, days of diarrhea, and number of diarrheal stools a minimum of 500 of 1000 iterations.
Conclusions: Intravenous rehydration is associated with unscheduled ED revisits after adjustment for clinical findings. Although children experiencing revisits were likely more unwell, our data do not support the provision of intravenous fluids to prevent unscheduled ED revisits in children with mild-to-moderate dehydration.
*Sections of Pediatric Emergency Medicine
†Gastroenterology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta
‡Divisions of Paediatric Emergency Medicine and Child Health Evaluative Sciences, The Hospital for Sick Children
§Biostatistics Department, University Health Network
||Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Address correspondence and reprint requests to Stephen B. Freedman, MDCM, MSc, Divisions of Pediatric Emergency Medicine and Gastroenterology, Alberta Children's Hospital, 2888 Shaganappi Trail NW, Calgary, Alberta T3B 6A8, Canada (e-mail: email@example.com).
Received 5 February, 2013
Accepted 17 June, 2013
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.jpgn.org).
This study was presented at the 2012 Pediatric Academic Society Annual Meeting, April 30, 2012 in Boston, MA.
A study reporting on the same group of patients was published in JPGN in 2012 (54:381–6. Because of the vastly different emphasis of the other article, the data that they contain could not be combined into a single manuscript.
This work was financially supported by the Division of Pediatric Emergency Medicine, The Hospital for Sick Children. The study sponsors played no role in study design or data collection, analysis, and interpretation or in the writing of the article and the decision to submit it for publication; all researcher activities were independent of the funding source; and the research team had full and unrestricted access to all the data.
S.B.F. is conducting a study using study product (ondansetron/placebo) from GlaxoSmithKline. The other authors report no conflicts of interest.