Skip Navigation LinksHome > October 2013 - Volume 57 - Issue 4 > C-ANCA/Proteinase 3–Positive Colitis in Children: A Distinc...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e31829d4e9e
Original Articles: Gastroenterology

C-ANCA/Proteinase 3–Positive Colitis in Children: A Distinctive Form of Inflammatory Bowel Disease or Vasculitis With Colitis as Initial Presentation?

Van Biervliet, Stephanie*; Bonroy, Carolien; Velde, Saskia Vande*; De Bruyne, Ruth*; Van Winckel, Myriam*; Peeters, Harald; Delanghe, Joris; Stove, Veronique; De Vos, Martine

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Abstract

Aim: Anti-neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase-3 (PR3) are rare in this context.

Methods: Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA-indirect immunofluorescence and its specific antibodies to investigate whether PR3-ANCA positivity (PR3-ANCA+) identifies a distinct IBD subtype.

Results: The 5 PR3-ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (P < 0.05). None had vasculitis features at diagnosis nor during follow-up.

Conclusions: This pilot study demonstrates significant clinical differences between the PR3-ANCA–positive and –negative IBD subset.

© 2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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