Share this article on:

Effectiveness of Trimethoprim-Sulfamethoxazole and Metronidazole in the Treatment of Small Intestinal Bacterial Overgrowth in Children Living in a Slum

Tahan, Soraia*; Melli, Lígia Cristina F.L.; Mello, Carolina Santos; Rodrigues, Mírian Silva C.; Filho, Humberto Bezerra; de Morais, Mauro B.*

Journal of Pediatric Gastroenterology and Nutrition: September 2013 - Volume 57 - Issue 3 - p 316–318
doi: 10.1097/MPG.0b013e3182952e93
Original Articles: Gastroenterology

ABSTRACT Trimethoprim-sulfamethoxazole and metronidazole were used for 14 days to treat 20 children with small intestine bacterial overgrowth (SIBO). SIBO was diagnosed using the lactulose hydrogen breath test. The breath test was repeated 1 month after treatment, and 19 (95.0%) of 20 children showed no evidence of SIBO (P < 0.001). The area under the individual curves showed that children with SIBO exhibited greater hydrogen production before treatment in both the first hour and between 60 and 180 minutes after the breath test. The treatment did not decrease methane production. In conclusion, trimethoprim-sulfamethoxazole and metronidazole was effective in treating children with SIBO.

*Pediatric Gastroenterology Division, Pediatric Department, Federal University of São Paulo (UNIFESP), São Paulo

University Center FIEO (UNIFIEO) - Foundation of Education for Osasco, Osasco, São Paulo, Brazil.

Address correspondence and reprint requests to Mauro Batista de Morais, Pediatric Gastroenterology Division, Pediatric Department, Federal University of São Paulo (UNIFESP), Rua Coronel Lisboa, 826, CEP-04020–000, São Paulo-SP, Brazil. (e-mail:

Received 7 September, 2012

Accepted 27 March, 2013

The pharmaceutical support for this work was provided by Daiichi Sankyo Brasil Farmacêutica LTDA, São Paulo, SP, Brazil.

The authors report no conflicts of interest.

© 2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,