Skip Navigation LinksHome > September 2013 - Volume 57 - Issue 3 > Effectiveness of Trimethoprim-Sulfamethoxazole and Metronida...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e3182952e93
Original Articles: Gastroenterology

Effectiveness of Trimethoprim-Sulfamethoxazole and Metronidazole in the Treatment of Small Intestinal Bacterial Overgrowth in Children Living in a Slum

Tahan, Soraia*; Melli, Lígia Cristina F.L.; Mello, Carolina Santos; Rodrigues, Mírian Silva C.; Filho, Humberto Bezerra; de Morais, Mauro B.*

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ABSTRACT: Trimethoprim-sulfamethoxazole and metronidazole were used for 14 days to treat 20 children with small intestine bacterial overgrowth (SIBO). SIBO was diagnosed using the lactulose hydrogen breath test. The breath test was repeated 1 month after treatment, and 19 (95.0%) of 20 children showed no evidence of SIBO (P < 0.001). The area under the individual curves showed that children with SIBO exhibited greater hydrogen production before treatment in both the first hour and between 60 and 180 minutes after the breath test. The treatment did not decrease methane production. In conclusion, trimethoprim-sulfamethoxazole and metronidazole was effective in treating children with SIBO.

© 2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,


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