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High- Versus Low-Volume Polyethylene Glycol Plus Laxative Versus Sennosides for Colonoscopy Preparation in Children

Kierkus, Jaroslaw*; Horvath, Andrea; Szychta, Monika*; Woynarowski, Marek*; Wegner, Agnieszka*; Wiernicka, Anna*; Dadalski, Maciej*; Teisseyre, Mikolaj*; Dziechciarz, Piotr

Journal of Pediatric Gastroenterology & Nutrition: August 2013 - Volume 57 - Issue 2 - p 230–235
doi: 10.1097/MPG.0b013e3182950ef5
Original Articles: Gastroenterology

Objective: Many protocols of bowel preparation are available for use in children; however, none of them is commonly accepted. The aim of the study was to evaluate the efficacy and acceptability of high-volume polyethylene glycol (PEG) versus low-volume PEG combined with bisacodyl (BPEG) versus sennosides for colonoscopy preparation in children.

Methods: Participants ages 10 to 18 years were randomly assigned to receive either PEG 60 or PEG 30 mL kg−1 day−1 plus oral bisacodyl 10 to 15 mg/day or sennosides 2 mg kg−1 day−1 for 2 days. A blinded assessment of bowel cleansing was made by the endoscopist according to the Aronchick and Ottawa scales. Patient acceptability was evaluated with the visual-analog scale. Analysis was done on an available case analysis basis.

Results: Of 240 patients enrolled in the study 234 patients were available for analysis of the efficacy of colon cleansing. There were no significant differences found among the 3 groups for the proportions of participants with excellent/good (PEG: 35/79, BPEG: 26/79, sennosides 25/76) and poor/inadequate (PEG: 20/79, BPEG: 28/79, sennosides 28/76) bowel preparation evaluated with the Aronchick scale and for the mean Ottawa total score (PEG: 5.47 ± 3.63, BPEG: 6.22 ± 3.3, sennosides: 6.18 ± 3.53). Acceptability of bowel cleansing protocol was similar in all of the groups (P = 0.8).

Conclusions: All 3 cleansing methods showed similar efficacy and tolerability; however, none of them was satisfactory.

*Department of Gastroenterology, Hepatology and Feeding Disorders, Children's Memorial Health Institute

Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland.

Address correspondence and reprint requests to Piotr Dziechciarz, MD, Department of Pediatrics, Medical University of Warsaw, Warsaw, Poland (e-mail: piotrdz@hotmail.com).

Received 31 January, 2013

Accepted 2 April, 2013

http://www.clinicaltrials.gov registration number: NCT01531140.

The authors report no conflicts of interest.

© 2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,