ABSTRACT: Major developmental paradigms are highly conserved among vertebrates. The contribution of developmental biology to the understanding of human disease and regeneration has soared recently. We review advances in the molecular and genetic understanding of gastrointestinal development using evidence from both mammalian and nonmammalian models. When appropriate, we highlight relevance and applicability to human disease.
Département de Pédiatrie, Faculté de Médecine, Hôpitaux Universitaires de Genève et Université de Genève, Genève, Switzerland.
Address correspondence and reprint requests to Dr Valérie A. McLin, Département de Pédiatrie, Hôpitaux Universitaires de Genève, 1211 Genève 14, Switzerland (e-mail: firstname.lastname@example.org).
Received 11 October, 2012
Accepted 24 January, 2013
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The present work was supported by the Swiss National Science Foundation (grant 31003A-132721) and the Gertrude von Meissner Foundation to V.A.M. and Hans Wilsdorf Foundation (Geneva, Switzerland) to V.D.
The authors report no conflicts of interest.