Major developmental paradigms are highly conserved among vertebrates. The contribution of developmental biology to the understanding of human disease and regeneration has soared recently. We review advances in the molecular and genetic understanding of gastrointestinal development using evidence from both mammalian and nonmammalian models. When appropriate, we highlight relevance and applicability to human disease.
Supplemental Digital Content is available in the text
Département de Pédiatrie, Faculté de Médecine, Hôpitaux Universitaires de Genève et Université de Genève, Genève, Switzerland.
Address correspondence and reprint requests to Dr Valérie A. McLin, Département de Pédiatrie, Hôpitaux Universitaires de Genève, 1211 Genève 14, Switzerland (e-mail: email@example.com).
Received 11 October, 2012
Accepted 24 January, 2013
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.jpgn.org).
The present work was supported by the Swiss National Science Foundation (grant 31003A-132721) and the Gertrude von Meissner Foundation to V.A.M. and Hans Wilsdorf Foundation (Geneva, Switzerland) to V.D.
The authors report no conflicts of interest.