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Calcium Ameliorates Diarrhea in Immunocompromised Children

Cheng, Sam X.*; Bai, Harrison X.; Gonzalez-Peralta, Regino*; Mistry, Pramod K.; Gorelick, Fred S.

Journal of Pediatric Gastroenterology & Nutrition: June 2013 - Volume 56 - Issue 6 - p 641–644
doi: 10.1097/MPG.0b013e3182868946
Original Articles: Gastroenterology

ABSTRACT: Treatment of infectious diarrheas remains a challenge, particularly in immunocompromised patients in whom infections usually persist and resultant diarrhea is often severe and protracted. Children with infectious diarrhea who become dehydrated are normally treated with oral or intravenous rehydration therapy. Although rehydration therapy can replace the loss of fluid, it does not ameliorate diarrhea. Thus, during the last decades, there has been continuous effort to search for ways to safely stop diarrhea. Herein, we report 3 immunocompromised children who developed severe and/or protracted infectious diarrhea. Their diarrheas were successfully “halted” within 1 to 2 days following the administration of calcium.

*Department of Pediatrics, University of Florida, Gainesville

Department of Pediatrics, Yale University, New Haven, Connecticut.

Address correspondence and reprint requests to Sam X. Cheng, MD, PhD, Department of Pediatrics, University of Florida, 1600 SW Archer Rd, RG-120, PO Box 100296, Gainesville, FL 32610 (e-mail:

Received 3 October, 2012

Accepted 7 January, 2013

The authors report no conflicts of interest.

Copyright 2013 by ESPGHAN and NASPGHAN