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Metabolic Effects of Roux-en-Y Gastric Bypass in Obese Adolescents and Young Adults

Sinha, Manasi*; Stanley, Takara L.*; Webb, Jessica*; Scirica, Christina; Corey, Kathleen; Pratt, Janey; Boepple, Paul A.*; Hoppin, Alison; Misra, Madhusmita*

Journal of Pediatric Gastroenterology & Nutrition: May 2013 - Volume 56 - Issue 5 - p 528–531
doi: 10.1097/MPG.0b013e318283910c
Original Articles: Gastroenterology

ABSTRACT: Weight loss surgery is an increasingly common treatment option for obese adolescents, but data are limited regarding the metabolic effects of surgical weight loss procedures. We performed a retrospective review of the electronic medical record to determine metabolic outcomes for 24 adolescents and young adults ages 15 to 22 years undergoing Roux-en-Y gastric bypass from 2009 to 2011 as well as 24 age-, sex-, and BMI-matched controls. During a median follow-up of 6 months after Roux-en-Y gastric bypass, fasting glucose, hemoglobin A1c, low-density lipoprotein, triglyceride, and high-sensitivity C-reactive protein decreased significantly. Changes in these measures were not significantly associated with age or extent of weight loss.

*Pediatric Endocrine Unit

Weight Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Address correspondence and reprint requests to Takara Stanley, MD, LON5-207, Massachusetts General Hospital, Boston, MA 02114 (e-mail:

Received 18 September, 2012

Accepted 17 December, 2012

Drs Sinha and Stanley were the co-first authors in this study.

Funding provided in part by National Institutes of Health T32HD052961 to M.S. and K23DK089910 to T.L.S., by the MGH Multicultural Affairs Office Summer Research Trainee Program to J.W., and by the American Association for the Study of Liver Disease Clinical and Translational Research Award to K.C.

The authors report no conflicts of interest.

© 2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,