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Newborn Lamb as a New Model for Studying Gastroesophageal Reflux

Djeddi, Djamal; Samson, Nathalie; Boudaa, Nadia; Praud, Jean-Paul

Journal of Pediatric Gastroenterology & Nutrition: December 2012 - Volume 55 - Issue 6 - p 745–746
doi: 10.1097/MPG.0b013e318263cae0
Short Communications

ABSTRACT: We aimed to determine whether the newborn lamb at term is a valid model for studying gastroesophageal reflux. Seven bottle-fed lambs, ages 2 to 3 days, underwent esophageal multichannel intraluminal impedance-pH monitoring (MII-pH). A total of 196 reflux episodes were recorded, including 73% alkaline and 27% weakly acidic. No acid refluxes were observed. Median bolus clearance time was 4 seconds (3; 5.5), and proximal reflux extent was 35% (26). This first report of MII-pH in the newborn mammal sets the foundations for future studies with physiological and clinical relevance to human neonates.

Neonatal Respiratory Research Unit, Department of Pediatrics and Physiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

Address correspondence and reprint requests to Djamal-Dine Djeddi, MD, PhD, Departments of Pediatrics and Physiology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada (e-mail: djamal-dine.djeddi@usherbrooke.ca).

Received 5 March, 2012

Accepted 7 June, 2012

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org).

D.D. was supported by the Department of Pediatrics, Amiens University Hospital, France. The study was also supported by grants from the Canadian Institutes of Health Research, the Canada Foundation for Innovation, and the Canada Research Chair in Neonatal Respiratory Physiology allocated to J.P.P. J.P.P. is a member of the FRSQ-funded Clinical Research Center Étienne-Le Bel, Sherbrooke University Hospital.

Copyright 2012 by ESPGHAN and NASPGHAN