Skip Navigation LinksHome > December 2012 - Volume 55 - Issue 6 > Newborn Lamb as a New Model for Studying Gastroesophageal Re...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e318263cae0
Short Communications

Newborn Lamb as a New Model for Studying Gastroesophageal Reflux

Djeddi, Djamal; Samson, Nathalie; Boudaa, Nadia; Praud, Jean-Paul

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ABSTRACT: We aimed to determine whether the newborn lamb at term is a valid model for studying gastroesophageal reflux. Seven bottle-fed lambs, ages 2 to 3 days, underwent esophageal multichannel intraluminal impedance-pH monitoring (MII-pH). A total of 196 reflux episodes were recorded, including 73% alkaline and 27% weakly acidic. No acid refluxes were observed. Median bolus clearance time was 4 seconds (3; 5.5), and proximal reflux extent was 35% (26). This first report of MII-pH in the newborn mammal sets the foundations for future studies with physiological and clinical relevance to human neonates.

Copyright 2012 by ESPGHAN and NASPGHAN


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