Skip Navigation LinksHome > December 2012 - Volume 55 - Issue 6 > ESPGHAN Guidance on Coeliac Disease 2012: Multiples of ULN...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e31826531f6
Short Communications

ESPGHAN Guidance on Coeliac Disease 2012: Multiples of ULN for Decision Making Do Not Harmonise Assay Performance Across Centres

Egner, William*; Shrimpton, Anna; Sargur, Ravishankar; Patel, Dina*; Swallow, Kirsty

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ABSTRACT: The updated ESPGHAN guidance on coeliac disease recommends the use of common multiples of the upper limit of normal (ULN) for IgA tissue transglutaminase antibodies (TG2) when deciding which diagnostic pathway to follow. The current lack of standardisation between assays makes it difficult to harmonise results between centres as different performance characteristics are observed with each assay. This variability is shown in data from external quality assessment distributions. As a result, the updated guidance is too generalised for use with all the commercial TG2 kits and is therefore not translatable for use in all centres.

Copyright 2012 by ESPGHAN and NASPGHAN


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