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Congenital Anomalies and Childhood Celiac Disease in Sweden

Wingren, Carl Johan*; Agardh, Daniel; Merlo, Juan*

Journal of Pediatric Gastroenterology & Nutrition: December 2012 - Volume 55 - Issue 6 - p 736–739
doi: 10.1097/MPG.0b013e318269f19d
Short Communications

ABSTRACT: Previously, chromosomal anomalies and, to a lesser extent, other congenital anomalies have been associated with an increased risk of celiac disease (CD). We investigated these associations using a systematic approach. We identified all of the singleton children (792,401) born in Sweden between 1987 and 1993, and obtained cases of CD using the Swedish National Inpatient Registry. We applied Cox regression models as well as sibling designs to study the association between congenital anomalies and childhood CD. We observed that anomalies of face, neck, ear, heart, digestive tract, or chromosomes were associated with CD.

*Department of Clinical Sciences, Unit for Social Epidemiology

Department of Clinical Sciences, Unit for Diabetes and Celiac Disease, Lund University, Malmo, Sweden.

Address correspondence and reprint requests to Carl J. Wingren, MD, Unit for Social Epidemiology CRC, Jan Waldenströmsgata 35, Skåne University Hospital, SE-20502 Malmö, Sweden (e-mail: carl_johan.wingren@med.lu.se).

Received 1 June, 2012

Accepted 16 July, 2012

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org).

This work was financially supported by the Centre for Economic Demography at Lund University, the Swedish Council for Working Life and Social Research (FAS) (Dnr 2010-0402, PI Juan Merlo), and the Swedish Research Council (VR) (Dnr K2011-69X-15377-07-6, PI Juan Merlo).

The authors report no conflicts of interest.

Copyright 2012 by ESPGHAN and NASPGHAN