Skip Navigation LinksHome > October 2012 - Volume 55 - Issue 4 > Rapid Test for Fecal Calprotectin Levels in Children With Cr...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e318253cff1

Rapid Test for Fecal Calprotectin Levels in Children With Crohn Disease

Kolho, KL*; Turner, D.; Veereman-Wauters, G.; Sladek, M.§; de Ridder, L.||; Shaoul, R.; Paerregaard, A.#; Dias, J. Amil**; Koletzko, S.††; Nuti, F.‡‡; Bujanover, Y.§§; Staiano, A.||||; Bochenek, K.¶¶; Finnby, L.##; Levine, A.***; Veres, G.†††

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ABSTRACT: Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95–0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100 μg/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined.

Copyright 2012 by ESPGHAN and NASPGHAN


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