ABSTRACT: Kawasaki disease (KD) is characterized by persistent fever in addition to 4 of 5 signs of mucocutaneous inflammation. Although gastrointestinal involvement does not belong to the classic diagnostic criteria, it has been often associated with KD onset. We reviewed patients who were admitted for febrile cholestatic jaundice between 2003 and 2010 in 2 tertiary pediatric care centers. KD was the second most frequent cause (21%) after viral infections. Considering the relative high frequency of this condition, a high index of suspicion of KD should be maintained in patients presenting with febrile cholestatic jaundice.
*Department of Pediatrics, Institute of Child Health IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
†Department of Pediatrics, University Hospital Santa Chiara, Pisa, Italy.
Address correspondence and reprint requests to Andrea Taddio, MD, Department of Pediatrics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, University of Trieste, Via dell’Istria 65/1, 34100 Trieste, Italy (e-mail: firstname.lastname@example.org).
Received 29 April, 2011
Accepted 5 March, 2012
The authors report no conflicts of interest.