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Protective Antibody Responses to Influenza A/H1N1/09 Vaccination in Children With Celiac Disease

Schäppi, Michela G.; Meier, Sara; Bel, Michael; Siegrist, Claire-Anne; Posfay-Barbe, Klara M.on Behalf of the H1N1 Study Group

Journal of Pediatric Gastroenterology and Nutrition: June 2012 - Volume 54 - Issue 6 - p 817–819
doi: 10.1097/MPG.0b013e318248e7be
Short Communications

ABSTRACT Patients with celiac disease have an increased risk for severe influenza infection and they show less of a response to certain vaccine types. During the influenza A/H1N1/09 pandemic, we prospectively investigated pandemic vaccine responses in 14 pediatric patients with celiac disease and age-/sex-matched controls. All of the children with celiac disease reached protective antibody titers (≥40) and showed a geometric mean titer comparable with the control group (530 vs 573).

Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.

Address correspondence and reprint requests to Dr Michela Schäppi Tempia, MD, PD, Pediatric Gastroenterology Unit, Children's Hospital of Geneva, 6, rue Willy-Donzé, 1211 Geneva 14, Switzerland (e-mail:

Received 14 October, 2011

Accepted 28 December, 2011

Drs Michela G. Schäppi and Sara Meier share first authorship.

This work was supported by an institutional grant of the Clinical Research Center of the University Hospitals of Geneva and Medical Faculty of Geneva and by the Center of Vaccinology. registration number: NCT01022905.

The H1N1 study group of the Geneva University Hospitals, Geneva, Switzerland: C.-A. Siegrist, K. Posfay-Barbe, S. Meier, M. Bel, S. Grillet, G. Sealy: Center for Vaccinology; J. Demeules, S. Charvat, M. Verdon, C. Combescure: Clinical Research Center; B. Hirschel, A. Calmy, A. Nguyen, C. Delhumeau-Cartier, J. Ambrosioni: Division of Infectious Diseases; C. Gabay, P.A. Guerne: Division of Rheumatology; J. Seebach, C. Ribi, J. Villard: Division of Immunology and Allergology; P.Y. Dietrich, A.C. George, L. Favet: Division of Oncology; C. van Delden, I. Morard, G. Mentha, E. Giostra: Division of Transplantation; K. Hadaya, P.Y. Martin: Division of Nephrology; P. Soccal: Division of Thoracic Surgery; T. Berney: Division of Visceral surgery; S. Noble: Division of Cardiology; B. Mohty, M. Nagy, Y. Chalandon, E. Roosnek, J. Passweg: Division of Hematology; L. Kaiser, S. Yerly, Y. Thomas, W. Wunderli: Laboratory of Virology; D. Belli: Department of Pediatrics.

The authors report no conflicts of interest.

Copyright 2012 by ESPGHAN and NASPGHAN